Document 0571
 DOCN  M9480571
 TI    Nitric oxide synthesis in patients with advanced HIV infection.
 DT    9410
 AU    Evans TG; Rasmussen K; Wiebke G; Hibbs JB Jr; Infectious Disease Section
       (111L), Salem VAMC, VA 24153.
 SO    Clin Exp Immunol. 1994 Jul;97(1):83-6. Unique Identifier : AIDSLINE
       MED/94306757
 AB    The discovery that humans produce nitric oxide and that this molecule
       plays an important role in cell communication, host resistance to
       infection, and perhaps in host defence to neoplastic disease, has
       created much interest in further research on its function in the body. A
       cytokine-inducible high output L-arginine/nitric oxide pathway was
       recently detected in patients with advanced malignancy treated with
       IL-2. The production of nitric oxide was thus examined in patients with
       advanced HIV infection and in intensive care unit control patients.
       Extrinsic nitrate and nitrite consumption were carefully controlled in
       the diet or through the use of total parenteral nutrition. Seven of
       eight HIV+ patients were placed into positive nitrogen balance. Nitric
       oxide synthesis was found to be within the normal human range. In
       contrast, nitric oxide synthesis in extremely ill intensive care unit
       patients was low normal to depressed.
 DE    Adult  Critical Illness  Diet  Female  Human  HIV Infections/*METABOLISM
       Male  Nitrates/ADMINISTRATION & DOSAGE/URINE  Nitric Oxide/*BIOSYNTHESIS
       Nitrogen/METABOLISM  Reference Values  Support, U.S. Gov't, Non-P.H.S.
       Support, U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).